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With "Grey's Anatomy" winding down its 19th season, we're taking a look at some of our favorite former Grey Sloan Memorial Hospital employees and finding out what the stars who played them are up to today. First up? T.R. Knight, who celebrates his 50th birthday on March 26, 2023.
T.R. Knight played Dr. George O'Malley on the hit series from 2004 until 2009. (He left after the fifth season after reportedly butting heads with executive producer Shonda Rhimes.)
Keep reading to find out what T.R. is up to now, plus check in with more "Grey's" alums today…
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T. R. Knight returned for one more "Grey's Anatomy" episode in 2020 but has otherwise stayed busy on other popular television shows. The actor did a stint on CBS's "The Good Wife" in 2013 and returned to ABC for a stint on the show "The Catch" in 2017. More recently, the star scored on a role on the popular HBO series "The Flight Attendant" opposite Kaley Cuoco. T.R. came out as a gay man during his time on "Grey's." He married longtime love Patrick B. Leahy in 2013.
MORE: Stars who came out
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We all fell in love with Dr. Sandra Oh's character, Dr. Cristina Yang, on "Grey's Anatomy" back in 2005. The actress starred on the show from its debut through 2014.
MORE: "Saturday Night Live" stars of the '70s: Where are they now?
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Sandra Oh has continued to make a name for herself after leaving Grey Sloan Memorial. The star lent her voice to a handful of children's series, like "Peg+Cat," "She-Ra and the Princesses of Power" and "Over the Moon." She also did some voice work in two Disney films, "Raya and the Last Dragon" and "Turning Red." But her biggest role since leaving the ABC medical drama came in 2018 with "Killing Eve." Her work on the British spy-thriller series earned her a Golden Globe Award in 2019.
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Isaiah Washington was an original "Grey's Anatomy" cast member who starred as Dr. Preston Burke beginning in 2005. He was fired from the show in 2007 after co-star T.R. Knight accused him of using homophobic slurs.
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Isaiah Washington, who returned to "Grey's Anatomy" for one episode in 2014, moved on to enjoy two lengthy stints on the CW series "The 100" as Thelonious Jaha from 2014 until 2018 and the Starz series "P-Valley" as Mayor Tydell Ruffin from 2020 until 2022. He wrote, directed and starred in the 2022 film "Corsicana" a year before announcing his retirement from Hollywood in March 2023 via a lengthy tweet.
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Sara Ramirez joined the cast of "Grey's Anatomy" as Dr. Callie Torres during the show's second season and remained through 2016, leaving after season 12.
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After leaving "Grey's Anatomy," Sara Ramirez — a Tony-winning Broadway star — came out as bisexual and, later, nonbinary. They've largely done voicework in recent years, lending their vocal talents to popular kids shows like "Elena of Avalor," "Vampirina" and "Sofia the First." In 2022, Sara returned to the small screen as Che Diaz on the "Sex and the City" reboot "And Just Like That." Sara was married to Ryan DeBolt from 2012 until 2021.
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Paging Dr. Izzie Stevens! Katherine Heigl brought the young doctor to life beginning in 2005… and in 2007 won a Primetime Emmy for her work on the show. She left the series in 2010, but not without some drama. She notably withdrew her name from Emmy contention in 2008 while offering a public statement claiming she was not "given the material this season to warrant an Emmy nomination." She also reportedly had some conflict with executive producer Shonda Rhimes.
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Katherine Heigl seemed to be making her mark as a movie star during her tenure on "Grey's Anatomy," famously starring in the comedy "Knocked Up" in 2007 and the rom-com "27 Dresses" in 2008, but she couldn't quite duplicate that success following her departure from the ABC show. She appeared in a string of forgettable films before switching gears and settling into an impressive television career. She appeared on NBC's "State of Affairs" in 2014 and CBS's "Doubt" in 2017. She also appeared on "Suits" from 2018 until 2019 and more recently has starred on the hit Netflix series "Firefly Lane." Off screen, Katherine has been married to singer Josh Kelley since 2006. They share three children.
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Patrick Dempsey starred as Dr. Derek Shepherd on "Grey's Anatomy" when the show first debuted in 2005 and remained through the first 11 seasons. McDreamy also returned for a stint during season 17 and appeared on two episodes of spinoff "Private Practice."
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Patrick Dempsey was already a big name before his run on "Grey's Anatomy" and he continued to score major roles after leaving the series. The year after he hung up his doctor's coat, Patrick starred in 2018's "Bridget Jones's Baby" alongside Renee Zellweger and Colin Firth. In 2022, he reprised his "Enchanted" role as Robert for Disney's "Disenchanted" and he's been starring on the Sky Original series "Devils" since 2020. Patrick shares three children with his second wife, Jillian Fink, who filed for divorce in 2015 but ultimately reconciled with the actor in 2016.
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Kate Walsh she was first introduced to "Grey's Anatomy" viewers in season 1 as Derek Shepherd's first wife, Dr. Addison Montgomery. She became a main cast member for seasons 2 and 3 before leaving the show for her own spinoff, "Private Practice," and guest appearances on "Grey's" during seasons 4 through 8 plus season 19.
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Kate Walsh's spinoff, "Private Practice," ran for six seasons from 2007 until 2013. She's also found success on Netflix, appearing on "13 Reasons Why," "The Umbrella Academy" and, more recently, "Emily in Paris." During her time as Dr. Addison Montgomery, Kate married 20th Century Fox exec Alex Young in 2007 but filed for divorce a year later. She shared happy romantic news with fans in 2022, revealing her engagement to Australian farmer Andrew Nixon following her relocation Down Under.
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Dr. Mark Sloan — aka McSteamy — was played by Eric Dane. Though originally only brought on as a guest star during season 2, fans instantly took to the hunky doc, who was made a main cast member and stuck around until his on-screen death in a season 8 plane crash. (He also appeared on the show's spinoff, "Private Practice," from 2009 until 2010).
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Eric Dane returned to the "Grey's Anatomy" universe in 2021 after starring on the TNT series "The Last Ship" from 2014 until 2018. He's also appeared on HBO's "Euphoria" since 2019. Eric was married to actress Rebecca Gayheart from 2004 until 2018. The couple share two daughters, Billie and Georgia.